可切除食道癌症的多式治疗方法
John Waters1, Marisa Sewell2, Daniela Molena2
1Division of Thoracic Surgery, Department of Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center, Dallas, Texas.
The Annals of thoracic surgery
|May 22, 2024
概括
多模式治疗,包括新辅助化疗和手术前的放射治疗,改善了切除食道癌的结果. 针对个性化治疗策略需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 目前的食道癌治疗指南强调采用多模式治疗方法.
- 尽管有进展,但治疗失败,转移和死亡率仍然很高.
研究的目的:
- 对可切除食道癌的新辅助多式疗法进行前性试验进行审查.
- 分析治疗疗效和生存结果.
主要方法:
- 关于1984-2022年试验的叙事文献综述.
- 关键词:"可切除的食道癌症"和"多式疗法".
- 对21项确定的临床研究 (15项RCT,6项前性非RCT) 的分析.
主要成果:
- 与单独手术相比,多种疗法 (新辅助化疗+/-辐射,随后进行手术) 显示出改善的局部控制和响应率.
- 通过多式联络方法,可能延长存活时间.
- 免疫疗法是一种新兴的治疗选择.
结论:
- 食道癌症的治疗正在不断发展,在过去的30年中取得了重大进展.
- 多式疗法提供了改善的生存潜力.
- 需要进一步研究机制,患者选择以及个性化,基于遗传学的方法.
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