纤维素素与循环中的基因素结合,可以防止不良的细胞和临床结果
Julien M Toh1, Jun Yong2, Simon T Abrams3
1Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK; Department of Anaesthetics and Critical Care, St George's University Hospitals NHS Foundation Trust, London, UK.
纤维素素中和有害的循环组织蛋白,减少细胞损伤和血小板问题. 监测基因组:纤维素比率可以识别患有严重疾病的患者,这些患者有很高的不良结果风险.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 在细胞死亡过程中释放的循环组质素有助于关键疾病的发病.
- 基因组与血成分的相互作用及其临床意义仍然不清楚.
研究的目的:
- 为了表征基因素-纤维素原相互作用.
- 探索这些相互作用在严重疾病中的功能和临床作用.
主要方法:
- 使用电泳和ELISA评估了基因组-纤维原结合亲和力.
- 实验室和体内模型 (血小板,内皮细胞,基因素输液小鼠) 用于评估功能意义.
- 对重症监护室 (ICU) 患者和COVID-19患者进行了回顾性队列研究,以进行临床验证.
主要成果:
- 纤维素因高亲和力结合基因组,减轻基因组诱导的内皮损伤和血小板聚合在体外和体内.
- 生理纤维素原水平可以中和低循环的组织蛋白,从而提高细胞毒性值.
- 在ICU患者中,较高的组织蛋白:纤维素比率 (≥6) 预测了血小板缩和死亡率,这一发现在COVID-19患者中得到了验证.
结论:
- 纤维素原作为缓冲剂,抵御循环中的基因组的细胞毒性作用.
- 监测循环中的基因组和它们与纤维素原的比率,可以识别高风险的重症患者.
- 这一比率可以指导在高危人群中使用抗希斯顿疗法.
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