退伍军人与海湾战争疾病运动后不引起运动后不适:一个随机的,受控的,剂量反应,交叉研究
Alexander E Boruch1, Ellen E Barhorst2, Tessa J Rayne3
1William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; University of Wisconsin-Madison, Madison, WI, USA.
Brain, behavior, and immunity
|May 22, 2024
概括
与休息相比,患有海湾战争疾病 (GWI) 的人在轻度,中度或剧烈运动后没有经历过更大的运动后不适 (PEM). 这些发现表明,运动的益处可能超过GWI患者的风险.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 运动生理学 运动生理学
背景情况:
- 慢性多症状疾病 (CMI),包括海湾战争疾病 (GWI),与炼后不适 (PEM) 有关.
- 了解运动强度对PEM的剂量反应影响对于个性化康复至关重要.
- 尽量减少PEM风险对于患有GWI的人来说至关重要.
研究的目的:
- 调查GWI的退伍军人中运动强度和PEM之间的剂量反应关系.
- 为了确定高强度运动是否会比低强度运动或休息加剧症状,疼痛,认知功能或炎症.
主要方法:
- 一个随机控制的交叉实验,涉及40名有GWI的退伍军人.
- 轻度,中度和强度的20分钟骑自行车与坐着的休息状态进行比较.
- 在干预前和后测量症状,疼痛敏感性,认知表现和炎症标志物,并通过动图监测身体活动.
主要成果:
- 对于症状,疼痛敏感性,认知表现或大多数炎症标志物,没有发现显著的条件对时间相互作用.
- 对于身体活动水平,没有观察到条件的显著主要影响.
- 虽然一些参与者经历了症状恶化,但与运动强度相比,与休息相比,小组级PEM风险没有增加.
结论:
- 在GWI的退伍军人中,运动后PEM的组级风险不大于坐着的休息.
- 这些发现挑战了以前关于PEM的假设,并支持了运动的好处超过风险的观点.
- 个性化炼处方可能有利于管理CMI,包括GWI.
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