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饮食维生素K与动脉样硬化心血管疾病之间的L形关系
Yue Wu1, Hong-Ju Xiang1, Min Yuan2
1Department of Cardiovascular Medicine, People's Hospital of Xiangxi Tujia and Miao Autonomous Prefecture, The First Affiliated Hospital of Jishou University, Jishou 416000, China.
Clinical nutrition ESPEN
|May 22, 2024
概括
饮食中摄入较高的维生素K与美国成年人患动脉样硬化心血管疾病 (ASCVD) 的风险降低有关. 保护作用似乎在每天127.1毫克左右稳定,这表明摄入量水平是最佳的.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 有限的研究探讨了维生素K摄入量与发生动脉样硬化心血管疾病 (ASCVD) 之间的联系.
- 这种潜在关系背后的精确生物机制尚不清楚.
- 这项研究调查了饮食维生素K消费与ASCVD患病率之间的关联.
研究的目的:
- 评估饮食维生素K摄入量与ASCVD发生之间的关系.
- 为了确定与ASCVD风险相关的维生素K的潜在值效应或最佳摄入水平.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) (2013-2018) 的横截面数据.
- 通过24小时的饮食回忆评估饮食维生素K摄入量.
- 使用患者医疗状况问卷诊断ASCVD.
- 采用后勤回归和立方支线模型进行统计分析,包括子组评估.
主要成果:
- 在14465名参与者中,9.78%的人患有ASCVD.
- 与摄入量最低四分位数 (Q1) 相比,较高四分位数 (Q2-Q4) 显示了降低ASCVD风险的趋势 (ORs从0.77到0.88).
- 在维生素K摄入量和ASCVD (p=0.006) 之间观察到一个显著的L形,非线性关联,转折点约为127.1μg/day.
结论:
- 饮食维生素K摄入量在美国成年人中表现出与ASCVD的L形关系.
- 大约127.1克/天的摄入量似乎是这种关联的关键值.
- 这些发现表明,适当的维生素K消费对ASCVD有潜在的保护作用.
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