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在一生中对先天性心脏病的临床风险评估和预测:JACC科学声明
Alexander R Opotowsky1, Paul Khairy2, Gerhard Diller3
1Adult Congenital Heart Disease Program, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Journal of the American College of Cardiology
|May 22, 2024
概括
准确测量先天性心脏病 (CHD) 的终身风险是复杂的. 本声明回顾了目前和未来的框架,以评估整个生命周期中不断变化的CHD风险.
科学领域:
- 心脏病学 心脏病学
- 医学科学 医学科学 医学科学
背景情况:
- 先天性心脏病 (CHD) 包含各种结构异常,具有独特的自然历史和长期结果.
- 目前用于CHD的风险预测模型面临着普遍性,验证性和长期适用性方面的挑战.
- 心血管疾病的风险评估因患者一生中不断变化的许多因素而复杂化.
研究的目的:
- 解决先天性心脏病终身风险测量方面的挑战.
- 评估现有的和新的CHD风险评估框架.
- 在整个生命周期中识别特定于心血管疾病的风险领域.
主要方法:
- 审查和评估当前和新兴的CHD风险测量框架.
- 分析影响心血管疾病不良结果的因素,包括年龄,性别,遗传学和并发症.
- 检查需要大型的,纵向的,具有多维数据的潜在的CHD队列的需求.
主要成果:
- 慢性心脏病中不良结果的风险是动态的,受到许多不断变化的因素的影响.
- 现有的预测模型在预测长期风险方面存在局限性.
- 新兴技术为改善风险评估提供了潜力,但需要验证.
结论:
- 准确的,终身风险评估在CHD至关重要,但具有挑战性.
- 需要强大的纵向数据和标准化的方法来对心血管疾病风险分层进行分层.
- 对患者和家人进行有效的风险沟通至关重要,需要最佳实践.
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