基于早期发现动脉样硬化的个性化干预:JACC最先进的技术审查
Rikke V Nielsen1, Valentin Fuster2, Henning Bundgaard3
1Department of Medical Science, Novo Nordisk Foundation, Hellerup, Denmark; Department of Cardiothoracic Anesthesiology, Rigshospitalet University Hospital Copenhagen, Copenhagen, Denmark.
心血管疾病 (CVD) 是一个主要的全球健康问题. 使用精准医学早期检测亚临床动脉样硬化,有机会预防心脏病发作和中风,将重点从晚期管理转移到早期干预.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 生物标志物 生物标志物
背景情况:
- 心血管疾病 (CVD) 是全球死亡的主要原因.
- 动脉样硬化是大多数心血管疾病病例的基础,并且会在几十年内发展.
- 早期发现亚临床动脉样硬化对于预防至关重要.
研究的目的:
- 倡导心血管疾病管理的范式转变.
- 探索早期检测亚临床动脉样硬化.
- 调查精准医学在心血管疾病预防中的作用.
主要方法:
- 审查动脉样硬化的病理生理学.
- 确定早期干预的机会.
- 建议使用成像和循环生物标志物.
主要成果:
- 动脉样硬化在生命早期开始,为预防提供了一个窗口.
- 目前的战略侧重于晚期管理,错过了预防机会.
- 精准医学有可能实现更早,更有效的检测.
结论:
- 需要向早期检测亚临床动脉样硬化症的模式转变.
- 精准医学方法可以在早期发现动脉样硬化.
- 需要进一步的研究来证实早期检测策略的成本效益.
更多相关视频
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
相关概念视频
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Cardiovascular Drugs: Classification based on Therapeutic Indications
Overview of Systemic Arteries
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Hypertension and Regulation of Blood Pressure
Pre-Procedural Guidelines for Assessing Blood Pressure
