在自我报告的无COVID-19儿童中,SARS-CoV-2的血清流行率
Hsiao-Lun Huang1, Chun-Yi Lu2, Yun-Chung Liu2
1Department of Pediatrics, Chi Mei Medical Center, Tainan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
概括
许多儿童有未检测到的COVID-19 (SARS-CoV-2) 感染,有血清学证据显示他们此前曾接触过. 家庭接触,特别是与母亲的接触,显著增加了儿童感染的风险.
科学领域:
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- COVID-19 (冠状病毒疾病2019) 对儿童构成重大风险.
- 在儿童中未检测到的SARS-CoV-2 (严重急性呼吸系统综合征相关的冠状病毒2) 感染病例使疾病负担评估复杂化.
- 这项研究解决了了解无症状或未报告的儿科感染的差距.
研究的目的:
- 为了确定具有之前SARS-CoV-2感染的血清学证据的儿童的比例,尽管报告没有先前的诊断.
- 确定与儿童血清阳性相关的危险因素.
主要方法:
- 招募19岁以下没有报告的SARS-CoV-2感染史的儿童 (2022年11月至2023年2月).
- 对IgG抗体的SARS-CoV-2抗体测试对核体 (N) 和尖端 (S) 蛋白进行抗体测试.
- 收集人口统计和家庭联系信息.
主要成果:
- 在没有报告先前感染的儿童中,整体抗N抗体阳性为9.2% (24/260),其比例因年龄而异 (4%-25%).
- 家庭接触,特别是与母亲的接触,显著提高了抗体阳性的可能性.
- 到2024年1月,累计感染率在最初对抗N抗体阴性儿童中达到41.9%.
结论:
- 以前未披露的SARS-CoV-2感染在儿童中很常见.
- 家庭传播是儿童COVID-19血清阳性的主要驱动因素.
- 临床医生应保持对儿童的SARS-CoV-2的警,即使是那些没有报告过先前接触的儿童.
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