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相关概念视频

Bioequivalence: Overview01:16

Bioequivalence: Overview

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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Synaptic Signaling01:09

Synaptic Signaling

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs01:21

Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs

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The fundamental mathematical principles, such as calculus and graphs, play crucial roles in analyzing drug movement and determining pharmacokinetic parameters. Differential calculus examines rates of change and helps to determine the dissolution rate of drugs in biofluids, as well as how drug concentrations change over time. For instance, it can help calculate the rate of elimination of a drug from the body based on its concentration-time profile.
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Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
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相关实验视频

Updated: Jun 25, 2025

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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CoRTEx:通过解释与应用构建生物医学知识图的应用来表示术语的对比学习.

Huaiyuan Ying1, Zhengyun Zhao1, Yang Zhao2

  • 1Center for Statistical Science, Department of Industrial Engineering, Tsinghua University, Beijing, 100084, China.

Journal of the American Medical Informatics Association : JAMIA
|May 22, 2024
PubMed
概括

通过解释表示术语的对比学习 (CoRTEx) 使用大型语言模型来改进生物医学术语集群. 这种方法提高了构建生物医学知识图的准确性和通用性.

关键词:
相反的学习学习学习.知识注入知识注入.大型语言模型.术语聚类是指术语聚类.

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科学领域:

  • 生物医学信息学 生物医学信息学
  • 人工智能的人工智能
  • 自然语言处理自然语言处理.

背景情况:

  • 生物医学知识图对研究至关重要.
  • 术语聚类,识别同义词,是构建这些图表的关键.
  • 现有的对比式学习模型与困难的术语扎,并且缺乏超出统一医疗语言系统 (UMLS) 的概括性.

研究的目的:

  • 增强术语表示和改善生物医学知识图的术语聚类.
  • 利用大型语言模型 (LLM) 的世界知识来克服以前模型的局限性.
  • 引入一种新的方法,即通过解释表示术语的对比学习 (CoRTEx).

主要方法:

  • 使用ChatGPT生成对UMLS术语的解释.
  • 采用对比式学习,同时嵌入术语和解释.
  • 引入了硬负样和一个ChatGPT辅助的BIRCH算法,以实现高效的集群.

主要成果:

  • 在已建立的集群和硬负测试集中,CoRTEx获得了最高的F1分数.
  • 从生物医学信息学本体系统 (BIOS) 聚合了超过3500万个术语,成为超过2200万个集群.
  • 通过案例研究证明了在处理具有挑战性的样品方面的有效性.

结论:

  • 与基准模型相比,CoRTEx显示出更高的准确性和稳定性.
  • 将术语与它们的解释对齐,可以提高聚类的性能.
  • 该方法适用于大规模的生物医学本体学术语集群.