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在皮质体垂体神经内分泌瘤亚型中的E-cadherin表达和基因表达特征

Katja Kiseljak-Vassiliades^1,2, Kristin Lipe^1,3, Christie G Turin¹

¹Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Journal of neuropathology and experimental neurology

|May 22, 2024

概括

E-cadherin表达不能预测皮质瘤 (PitNETs) 的行为. 活体和静态皮质otroph PitNETs 的分子特征相似,表明具有明显分泌差异的共同起源.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

皮质形腺瘤/垂体神经内分泌瘤 (PitNETs) 导致显著的发病率和死亡率,预后预测因素有限.
E-cadherin表达是已知的 somatotroph PitNETs 的预后标志物,但其在皮质otroph PitNETs 中的作用尚未被探索.

研究的目的:

调查E-cadherin表达与皮质形腺瘤/PitNETs中的瘤特征之间的相关性.
为了比较临床活跃和沉默的皮质otroph PitNETs的分子特征.

主要方法:

77名患有皮质腺瘤/PitNETs.的成年患者的回顾性图表审查.
免疫组织化学 (IHC) 对于E-cadherin和上皮质激素颗粒化模式.
对16种瘤的子集进行基因表达微阵列分析.

主要成果:

E-cadherin表达 (阳性,减弱或不存在) 与皮质变性PitNET亚型,大小或预后没有相关性.
密集颗粒 (DG) 微腺瘤是常见的;与稀疏颗粒 (SG) 相比,宏腺瘤在DG亚型中显示出更大的入侵.
活跃和静默的皮质变体PitNETs具有相似的分子特征,表明它们的起源相同,但分泌特征不同.

结论:

对于皮质营养不良的PitNETs,E-cadherin不是一个可靠的预后标志物.
瘤颗粒化模式 (DG与SG) 可能与入侵有关,特别是在宏腺瘤中.
皮质变性PitNETs,无论临床活动如何,都来自一个共同的细胞起源,具有与激素分泌相关的独特分子特征.

关键词:

CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 CDH1 皮质变质动物皮质变质动物库辛病是什么病?库辛病是什么病?密集的颗粒制造.这是E-cadherin.下垂体腺瘤是什么意思稀有颗粒剂的颗粒化方法

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