托西利祖马布与COVID-19重症患者的痴呆和昏迷的减少有关
Tuqa Alkhateeb1, Joanna L Stollings1,2, Ine Sohn3
1The Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Scientific reports
|May 22, 2024
概括
托西利祖马布 (tocilizumab) 是一种互白素-6 (IL-6) 抑制剂,在重症COVID-19患者中显著增加了没有妄想或昏迷的生存日数. 这一发现表明一种潜在的新治疗方法来减少危急疾病中的妄想.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 干白素-6 (IL-6) 途径在妄想表型中起着病理作用.
- 一种IL-6抑制剂托西利祖马布 (tocilizumab) 在重症COVID-19患者中显示出有前途.
- 妄想和昏迷是重症患者的重大并发症.
研究的目的:
- 为了测试托西利祖马布是否能降低COVID-19重病患者的痴呆症/昏迷症患病率.
- 为了评估托西利祖马布和妄无天之间的关联.
- 探索托西利祖马布对其他重症护理结果的影响.
主要方法:
- 对253名重症COVID-19患者的回顾性研究.
- 托西利祖马布组 (69名患者) 与历史对照组 (184名患者) 的比较.
- 由CAM-ICU评估的妄想;通过RASS分数 (-4或 -5) 评估的昏迷.
主要成果:
- 托西利祖马布组在没有狂妄症/昏迷的情况下活着的日数显著增加 (7 vs 3 天; p < 0.001).
- 经过多种混因素调整后,结果仍然显著.
- 没有观察到死亡率,呼吸器持续时间或停留时间的显著差异.
结论:
- 托西利祖马布的使用与没有狂妄症/昏迷的日数显著增加有关.
- 需要进一步的随机试验来证实这些发现.
- 托西利祖马布可能提供一种新的药理学方法来改善危急疾病中的妄想.
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