干细胞因子的血清水平用于预测胚胎质量
Joanna Liss1,2, Martyna Kuczyńska2, Michał Kunicki3,4
1Research and Development Center, INVICTA, Polna 64, 81-740, Sopot, Poland.
Scientific reports
|May 22, 2024
概括
排卵诱导前的血清干细胞因子 (s-SCF) 水平可以预测高质量的胚胎细胞发育. 在轻度子宫内膜异位症患者中,较低的s-SCF水平与成功的TQ芽细胞形成相关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 生物标志物发现发现
背景情况:
- 高质量的 (TQ) 胚胎细胞发育对于成功的体外受精 (IVF) 结果至关重要.
- 识别TQ芽细胞形成的预测标记可以优化生育治疗.
- 血清干细胞因子 (s-SCF) 是一种参与生殖过程的细胞因子.
研究的目的:
- 调查前排卵诱导血清干细胞因子 (s-SCF) 水平作为第5天TQ胚胎细胞发育的预测因子的潜力.
- 为了评估不同患者群体之间的这种关联,包括正常卵巢储量 (NOR),多囊性卵巢综合征 (PCOS),卵巢储量减少 (DOR) 和轻度子宫内膜异位症.
主要方法:
- 进行了一项试点研究,涉及接受排卵诱导的患者.
- 血清s-SCF水平在刺激的第8天和卵细胞检索之日被测量.
- 在第5天之前,患者根据TQ芽细胞形成进行了分类.
主要成果:
- 在患有轻度子宫内膜异位症 (p <0.05) 的患者中,观察到s-SCF水平和TQ芽细胞形成之间的统计学显著相关性.
- 平均s-SCF水平在TQ胚芽细胞子组显著低于非TQ子组在第8天 (28.07vs53.32ppg/ml) 和卵细胞检索日 (33.47vs52.23ppg/ml).
结论:
- 排卵诱导前的血清s-SCF水平可以作为TQ母细胞囊发育的预测生物标志物,特别是在患有轻度子宫内膜异位症的女性中.
- 需要进一步的研究来验证这些发现,并探索s-SCF在试管婴儿患者管理中的临床实用性.
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