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在非糖尿病,肥胖患者中,为减肥处方塞马格卢提德与勃起功能障碍的风险增加有关:一个TrinetX数据库研究
Corey Able1, Brian Liao1, Gal Saffati2
1Division of Urology, Department of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
International journal of impotence research
|May 22, 2024
概括
那些为减肥处方西马格卢提德的男性面临着明显更高的勃起功能障碍 (ED) 和缺乏症的风险. 这项研究强调了与这种流行的减肥药物相关的潜在性健康风险.
科学领域:
- 内分泌学和新陈代谢学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于非糖尿病肥胖个体的体重减轻已获批准的塞马格卢提德,将性功能障碍列为潜在的副作用.
- 在体重管理中使用塞马格卢提德后,性功能障碍的实际风险和程度,特别是勃起功能障碍 (ED),仍然未得到量化.
- 肥胖本身是ED和丸激素缺乏症的危险因素,需要仔细的研究设计来隔离塞马格卢提德的作用.
研究的目的:
- 为了评估非糖尿病,肥胖男性新发性勃起功能障碍 (ED) 的风险,他们为减肥处方了塞马格卢提德.
- 评估同一个患者队列中发展激素缺乏症的二次风险.
- 通过对匹配的对照组进行比较分析来量化这些风险.
主要方法:
- 一项使用TriNetX研究数据库的回顾性队列研究.
- 确定的非糖尿病男性 (BMI > 30,年龄18-50岁) 在2021年6月之后被处方西马格卢提德.
- 排除了先前存在的ED,相关治疗或影响性功能/水平的条件的个人.
- 根据人口统计和健康状况,将塞马格卢提德使用者与非使用者匹配.
- 主要结局:新的ED诊断或固酶5型抑制剂的处方.
- 二次结果:新诊断的缺乏症.
主要成果:
- 3,094名接受塞马格卢提德处方的男性与3,094名对照人群进行了匹配.
- 塞马格卢提德使用者显示ED和/或固酶5型抑制剂处方的发生率显著更高 (1.47%对0.32%;RR:4.5;95%CI [2.3,9.0]).
- 在西马格卢提德组中也观察到较高的丸激素缺乏风险 (1.53%对0.80%;RR: 1.9;95%CI [1.2, 3.1]).
结论:
- 对非糖尿病,肥胖男性减肥的塞马格卢提德处方与患勃起功能障碍的风险增加有关.
- 这种药物还与丸激素缺乏症的风险增加有关.
- 需要进一步研究这些潜在副作用的机制和临床管理.
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