对低强度冲击波疗法用于勃起功能障碍的能量密度和脉冲频率的间接评估:系统性审查,贝叶斯网络元分析和元回归
David E Hinojosa-Gonzalez1,2, Alejandro Talamas Mendoza3, Mauricio Torres-Martinez3
1Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave Morones Prieto 3000, Monterrey, NL, 64000, Mexico. David.Hinojosa-Gonzalez@bcm.edu.
International journal of impotence research
|May 22, 2024
概括
低强度冲击波疗法有效治疗勃起功能障碍. 通过每次1500次脉冲和0.15mJ/mm2的能量密度观察到最佳结果,显著改善了患者的治疗结果.
科学领域:
- 再生医学是一种再生医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物医学工程 生物医学工程
背景情况:
- 冲击波可以刺激再生和血管生成途径.
- 勃起功能障碍 (ED) 是一种具有冲击波治疗潜在治疗益处的疾病.
- 之前的研究表明,低强度体外冲击波治疗 (LI-ESWT) 参数的有效性各不相同.
研究的目的:
- 系统地分析LI-ESWT对勃起功能障碍的有效性.
- 为了确定LI-ESWT在ED治疗中的最佳能量密度和脉冲频率参数.
- 用贝叶斯网络元分析来比较LI-ESWT与对照或假冒程序的疗效.
主要方法:
- 2022年5月随机临床试验 (RCT) 的系统搜索.
- 包括18个RCT,包括1272名患者,将LI-ESWT与对照进行比较.
- 用20万个马尔科夫链进行贝叶斯网络元分析,以比较不同的能量密度和脉冲频率.
主要成果:
- 在国际勃起功能指数 (IIEF) 中,LI-ESWT显示出显著的改善.
- 能量流密度为0.15mJ/mm2显示了提高IIEF评分的最高排名 (SUCRA=0.983).
- 1500个脉冲/会议为IIEF改善提供了最高的有效性排名 (SUCRA=0.996).
结论:
- LI-ESWT是治疗勃起功能障碍的有效干预措施.
- 1500脉冲/会话和0.15mJ/mm2能量流量密度的组合似乎是改善IIEF-EF分数的最有效方法.
- 进一步的研究可能会完善LI-ESWT协议,以实现最佳的ED管理.
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