对降低脂蛋白的治疗选择的新见解 (a)
A Baragetti1, L Da Dalt1, G D Norata1
1Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università Degli Studi di Milano, Milano, Italy.
European journal of clinical investigation
|May 22, 2024
概括
升高的脂蛋白 (Lp) 是一个心血管疾病的风险. 针对Lp (a) 的新疗法显示有望减少心血管事件和死亡率.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
背景情况:
- 升高的脂蛋白 (Lp) 是心血管疾病 (CVD) 的重要危险因素,包括大动脉狭窄,心肌梗塞和中风.
- 遗传研究表明,降低Lp(a) 水平可以独立于其他危险因素提供心血管保护.
- Lp(a) 被认为是预防心血管疾病的令人信服的药理目标.
研究的目的:
- 审查新兴的治疗策略,以选择性地向脂蛋白 (Lp) 降低心血管风险.
- 讨论新型Lp(a) 降低剂的临床开发.
主要方法:
- 审查针对Lp的当前和研究中的治疗方法.
- 专注于反感 oligonucleotides,小干扰RNAs (siRNAs),阿波利波蛋白a (Apoa) 抑制剂,以及CRISPR-Cas9基因编辑.
- 考虑正在进行的心血管结局试验.
主要成果:
- 标准的降脂疗法对Lp (a) 水平的影响有限.
- 针对Apo (a) 的反意义寡核酸和siRNA处于先进的临床开发阶段.
- 新的方法,如Apo(a) 抑制剂和CRISPR-Cas9,正在进入临床早期阶段.
结论:
- 心血管结局试验的积极结果表明Lp(a) 降低 (例如,Pelacarsen,Olpasiran,Lepodisiran>80%),可以将Lp(a) 降低作为一种新的护理标准.
- 这将为管理心血管风险较高的患者提供额外的治疗目标.
相关概念视频
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
647
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
647
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
154
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
154
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
155
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
155
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
167
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
167
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
681
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
681
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
157
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
157