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Updated: May 12, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
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整合单细胞和空间分析揭示了MUC1介导的细胞交叉在粘膜结直肠腺癌中的细胞交叉

Haiyang Zhou1,2, Yiwen Shen1, Guangyong Zheng1

  • 1Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Clinical and translational medicine
|May 23, 2024
PubMed
概括

这项研究揭示了粘性结直肠腺癌 (MCA) 中的关键细胞相互作用,确定了MUC1+瘤细胞和FGF7+/THBS1+肌纤维细胞作为关键驱动因素. MS4A4A+巨细胞和ZEB1+内皮细胞也在MCA进展和预后中发挥着重要作用.

关键词:
粘性结肠直肠腺癌癌.在 scRNA-seqq 中.空间转录学 空间转录学瘤微环境是一个微环境.

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...