在多发性硬化症中使用7TMRI测量缓慢扩大的病变的纵向髓含量
Mina M Huerta1, Devon S Conway2, Sarah M Planchon2
1School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
概括
与其他病变相比,多发性硬化症中缓慢扩大的病变 (SEL) 显示了较低的髓含量和随着时间的推移更大的组织损伤. 高级MRI揭示了这些差异,突出了SELs作为疾病进展的标志物.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 缓慢扩张的病变 (SELs) 是多发性硬化症中慢性活跃病变的一个子集.
- SEL与增加的临床残疾,疾病严重程度和进展有关.
研究的目的:
- 使用先进的7特斯拉 (T) MRI来描述SEL.
- 在SEL中评估髓和神经质密度.
主要方法:
- 对15名多发性硬化症患者进行了回顾性纵向队列研究.
- 使用7T磁扫描仪进行先进的MRI测序 (ViSTa,qMT,NODDI).
- 定义SEL为12个月内≥12%增长的病变;比较SEL和非SEL之间的定量MRI测量.
主要成果:
- 在1075个病变中,21%被确定为SEL;96%的SEL是黑洞.
- 在基线时,SELs比非SELs具有明显较低的髓测量 (ViSTa,qMT).
- 纵向看,SELs与非SELs相比,表现出髓水分数 (ViSTa) 的较大降低.
结论:
- 与非SEL相比,SELs的髓含量减少.
- 没有观察到SEL和非SEL之间神经质密度测量的显著差异.
- 在SEL中,纵向髓损失表明组织损伤和潜在的疾病进展更大.
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