通过口服胆酸盐挑战试验量化的肝功能和门系统变流,以及大食道静脉的风险
Tarek Hassanein1, Andrew P Keaveny2, Parvez Mantry3
1Southern California Research Center, Coronado, California, USA.
Alimentary pharmacology & therapeutics
|May 23, 2024
概括
肝功能测试HepQuant DuO准确预测大食道静脉 (LEVs) 的风险,类似于SHUNT测试. 这种微创试验可以帮助避免不必要的内镜检查.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 诊断成像和光谱学 诊断成像和光谱
- 生物标志物发现发现
背景情况:
- 肝量SHUNT测试量化肝功能和生理学,产生与临床并发症相关的疾病严重程度指数 (DSI),如大食道静脉 (LEVs).
- Quant DuO测试提供了一个简化的,最少的侵入性替代方案,只需要口服和两个血液样本来产生相当的DSI.
研究的目的:
- 为了比较HepQuant DuO测试的DSI与SHUNT测试的诊断性能,用于识别大食道静脉 (LEV).
主要方法:
- 结合了来自美国两项前性研究 (HALT-C和SHUNT-V) 的数据,涉及455名受试者.
- 受试者接受了SHUNT测试和食道胃管腺镜 (EGD) 进行水评估.
主要成果:
- DSI得分与LEVs概率 (p < 0.001) 有显著的相关性,并且在疾病严重程度方面逐步增加.
- HepQuant DuO DSI在LEVs检测上获得了0.98的灵敏度,并且可以预防41.3%的EGDs.
- 双O DSI的诊断性能 (AUROC) 与SHUNT测试 (0.82与0.81对比,p=0.3500) 相似.
结论:
- 在不同患者群体中,HepQuant DuO的DSI有效地将肝功能与LEVs风险联系起来.
- 该测试是最少的侵入性,易于管理,和定量.
- 杜奥可以协助临床决策关于需要EGD来诊断LEVs.
更多相关视频
04:00Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
166
09:37Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
15.0K
相关概念视频
01:28Esophageal Varices-II: Clinical Features and Management
60
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
60
01:24Esophageal Varices-I: Introduction
111
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
111
01:21Hepatic Portal System
1.2K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.2K