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胃癌免疫微环境评分预测了新辅助化疗的疗效和预后

Shaoji Zhao¹, Yinan Liu¹, Li Ding²

¹Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China.

The journal of pathology. Clinical research

|May 23, 2024

概括

透瘤的免疫细胞预测了晚期胃癌 (GC) 中的新辅助化疗 (NACT) 反应. 免疫微环境评分 (ISGC) 有效地预测NACT的疗效和患者的存活率,指导个性化免疫疗法策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

在晚期胃癌 (GC) 中,新辅助化疗 (NACT) 的疗效是高度可变的.
了解瘤免疫微环境 (TIME) 对于预测治疗反应和患者的结果至关重要.

研究的目的:

评估瘤透免疫细胞 (TIICs) 对NACT反应和预后的预测价值.
为了研究NACT对GC患者的时间的影响.
为GC (ISGC) 开发免疫微环境评分,以预测NACT的疗效.

主要方法:

分析了晚期GC患者的配对瘤组织 (NACT前和后).
免疫组织化学被用来评估TIICs.
使用后勤回归和卡普兰-梅尔曲线来制定ISGC得分并评估生存结果.

主要成果:

时代在NACT响应者和非响应者之间显示出显著的异质性.
在ISGC得分显示强大的预测性表现NACT响应和长期生存.
NACT改变了TIIC种群,增加了T细胞 (CD3 +,CD8 +) 和CD11c +巨细胞,同时减少了响应者的CD163 +巨细胞和FOXP3 + Treg细胞.
编程细胞死亡配体1 (PD-L1) 表达在NACT后增加,特别是在响应者中.

结论:

ISGC模型准确地预测了NACT疗效和高级GC患者的患者存活率.
NACT调节了GC中的TIME,这表明了个性化免疫治疗方法的潜力.
在胃癌中,TIIC分析为优化NACT和免疫疗法提供了有价值的策略.

关键词:

在PD-L1中.胃癌胃癌是一种胃癌.新辅助性化疗是一种新辅助性化疗.瘤免疫的微环境瘤透的免疫细胞

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