怀孕期间物质使用的查:一项丹麦横截面研究
Nete Lundager Klokker Rausgaard1,2, Inge Olga Ibsen2, Palle Bach Nielsen Fruekilde3
1Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Acta obstetricia et gynecologica Scandinavica
|May 23, 2024
概括
尼古丁是丹麦孕妇使用的主要物质. 尿液测量棒查在怀孕期间的药物使用有局限性,对于某些物质,自我报告通常是足够的.
科学领域:
- 产科和妇科 产科和妇科
- 公共卫生 公共卫生
- 临床药理学 临床药理学
背景情况:
- 关于丹麦孕妇使用物质的客观数据有限.
- 估计酒精和尼古丁使用的流行率对于母亲和儿童的健康至关重要.
研究的目的:
- 估计在丹麦孕妇的一般人口中使用物质的流行程度,包括酒精和尼古丁.
- 与尿液查方法相比,评估自我报告的准确性.
主要方法:
- 一项涉及1903名孕妇的全国性,横截面,描述性研究.
- 在超声波扫描期间进行的匿名尿样采集和调查问卷.
- 在现场对15种物质进行尿液测量棒查,通过液体染色学-并联质谱学 (LC-MS/MS) 证实了阳性结果.
主要成果:
- 已确认的物质使用率为10.8%,尼古丁使用率为10.1%.
- 年轻孕妇的尼古丁使用率较高;其他物质的使用均分布.
- 自我报告的准确性各不相同,尼古丁报告高,酒精和大麻报告低.
结论:
- 尼古丁是丹麦孕妇使用的主要物质.
- 尿液测量棒查带有虚假阳性/负性的风险,并为某些物质提供有限的额外价值,而不是自我报告.
- 液体染色学-双重质谱学 (LC-MS/MS) 仍然是物质检测的黄金标准.
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