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绿色合成纳米颗粒具有抗糖尿病特性的表征. 一个系统的审查
Alejandra Loyola-Leyva1, Karen Hernandez-Vidales2, Jaime Ruiz-Garcia1
1Biological Physics Laboratory, Physics Institute. Autonomous University of San Luis Potosí, (Universidad Autónoma de San Luis Potosí), Av. Manuel Nava #6, Zona Universitaria, C.P. 78290, San Luis Potosí, S.L.P., México.
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概括
来自植物的绿色合成纳米粒子 (GSNPs) 显示出显著的抗糖尿病特性,有效抑制关键酶并改善动物模型中的代谢概况. 鉴定性对于它们在糖尿病管理中的生物医学应用至关重要.
科学领域:
- 纳米医学是一种纳米医学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 植物提供低成本,易于获得的治疗化合物,副作用比常规药物少.
- 具有抗糖尿病特性的植物化学物质可以有效地使用纳米颗粒 (NP) 输送.
研究的目的:
- 审查和描述绿色合成纳米粒子 (GSNPs) 的抗糖尿病特性.
- 概述用于这些GSNP的表征方法.
主要方法:
- 在三个数据库中进行了系统的文献搜索,使用与2型糖尿病,抗糖尿病作用,植物化学物质,植物和纳米颗粒相关的关键词.
- 包括的研究涉及糖尿病的实验室或动物模型,重点是从植物提取物合成的NP,并以UV-Vis光谱,FTIR,XRD,SEM,TEM和DLS等技术为特征.
主要成果:
- 在体外研究中,显著抑制了α-氨基酶 (11-100%) 和α-葡萄糖酶 (41.1-100%).
- 动物研究表明,GSNP有效地降低了血糖,甘油三,总胆固醇和LDL,同时改善了糖尿病老鼠的HDL水平.
- 鉴定显示了NP大小从8.7到181.5纳米,泽塔电位从-30.7到-2.9mV,并证实了AgNP,AuNP和ZnONP的形成.
结论:
- 对GSNP (大小,形状,电荷) 的表征对于评估生物医学应用中的稳定性和有效性至关重要.
- GSNP 显示出有希望的 * in vitro * 酶抑制和 * in vivo * 改善血糖和脂质概况.
- 当前研究的方法限制和潜在偏见需要仔细解释结果和进一步研究.
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