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通过基于新的目标彻底改变不孕症管理

Vijay Kumar¹, Gaurav Doshi¹

¹Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai 400 056, India.

Current protein & peptide science

|May 23, 2024

概括

不孕症影响全球数以百万计的人. 像基斯佩普丁,神经-B和Orexin这样的新可以通过调节关键激素来治疗生殖障碍.

科学领域:

生殖内分泌学生殖内分泌学
神经内分泌学神经内分泌学
分子生物学分子生物学

背景情况:

不孕症影响全球4800万对夫妇,在85%的病例中存在可识别的原因.
排卵功能障碍,男性因素,PCOS和输卵管疾病是常见的原因.
下垂体-垂体-上腺 (HPA) 轴调节生殖激素,这对生育至关重要.

研究的目的:

审查基斯佩普丁 (KP),神经-B (NKB) 和Orexin的历史视角,异型和信号通路.
探索用于不孕症管理的基于的新型治疗点.
总结关于这些在生殖健康中的临床和临床前发现.

主要方法:

文献综述侧重于历史数据和当前研究.
分析KP,NKB和Orexin的信号通路和反机制.
对基于的不孕症治疗方法的临床和临床前研究结果的综合.

主要成果:

KP,NKB和Orexin是激素释放激素 (GnRH),黄素化激素 (LH) 和卵泡刺激激素 (FSH) 分泌的关键调节剂.
这些会影响生殖轴中的正负反循环.
新出现的证据表明,它们在治疗各种不孕症原因方面具有治疗潜力.

结论:

基斯佩普丁,神经-B和奥雷克辛代表了不孕不育的有前途的新型标.
了解它们在调节HPA轴上的复杂作用,对于开发有效的治疗方法至关重要.
需要进一步的临床和临床前研究,以优化它们在生殖医学中的使用.

关键词:

信号通道的信号通道.发生性腺激素释放激素下垂体-垂体-上腺轴.不孕症不孕不育不孕不育不孕不育亲吻peptin 的时间神经基因素-bb 的使用.甲素是一种矿物质.

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