外源性表面活性剂用于引起ARDS的肺伤:临床和实验报告的系统审查
Tomáš Merkl1,2,3, David Astapenko4,5, Radek Štichhauer2,3
1Military Faculty of Medicine, Department of Military Surgery, University of Defence, Hradec Kralove, Czech Republic.
The clinical respiratory journal
|May 23, 2024
概括
外源表面活性剂治疗改善了肺部伤患者的肺功能. 来自动物的表面活性剂,如Curosurf®,通过支气管镜检查,似乎最有效,减少通风时间和需要积极的支持.
科学领域:
- 肺部医学 肺部医学
- 临界护理医学 临界护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺是创伤患者常见的伤害.
- 严重的肺伤的治疗选择有限.
- 外源表面活性剂在改善肺功能方面显示出潜力.
研究的目的:
- 系统地审查对外源表面活性剂治疗肺伤的数据.
- 在严重情况下评估表面活性剂的益处.
- 为了确定最佳的表面活性剂类型,施用方法和度.
主要方法:
- 对MEDline,Scopus和Web of Science数据库的系统审查 (1945年至2023年2月).
- 关键词:肺表面活性剂,外源表面活性剂,肺伤,肺伤.
- 包含六篇文章:2项临床研究,2项实验,2项病例报告.
- 由八名审查员进行独立审查和冲突解决.
主要成果:
- 在所有包括的研究中,表面活性剂的使用始终改善了通风参数.
- Curosurf®是最常用的表面活性剂,其理想体重为25mg/kg.
- 将支气管镜注入细分支气管是首选的方法.
- 临床研究表明,接受表面活性剂的患者的通风时间更短.
结论:
- 外源表面活性剂的使用可增强肺伤患者的呼吸系统参数.
- 这种治疗可以减少对激烈机械通风的需要,并缩短通风时间.
- 虽然Curosurf®似乎很适合,但最佳度需要进一步研究.
- 对细分支气管进行支气管镜检查是推的给药途径.
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