术前血液学参数与直肠癌的短期临床结果的关联:特征重要性分析
Ala Orafaie1, Fatemeh Shahabi1, Ali Mehri1
1Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Cancer medicine
|May 23, 2024
概括
术前血液学参数如NLR,MPV和PDW可以预测直肠癌患者的死亡率和复发率. 这些标记物,以及血小板计数和PLR,对于评估预后和预防不良结果是有价值的.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 医学统计 医学统计
背景情况:
- 人们还在讨论直肠癌的预后因素.
- 手术前的血液学参数需要进一步调查它们在预测结果中的作用.
研究的目的:
- 评估手术前的血液学参数作为术后患病率和死亡率的预测指标,用于治疗切除的直肠癌患者.
- 评估血液学参数在识别患有手术感染并发症,复发和死亡风险的患者中的能力.
主要方法:
- 对200名直肠癌患者的回顾性分析.
- 使用的接收器操作特征 (ROC) 曲线和机器学习 (ML) 算法 (随机森林,RFE,SA,SVM,决策树,XGBoost).
- 研究的血液学参数 (NLR,MPV,PDW,PLT,PLR) 和临床结果的基线特征.
主要成果:
- 瘤复发与T和N阶段有关;死亡率与T,N阶段相关,以及切除边缘的参与.
- 对NLR,MPV,PDW,PLT和PLR的特定值被确定为死亡率和复发的重要预测指标.
- 血液学参数没有显著预测手术感染性并发症.
结论:
- 手术前的血液学参数是直肠癌术后结果的显著预后因素.
- 临床医生应监测这些血液学标记,以预测和预防不良结果.
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