在SOL-INCA-MRI研究中,心血管疾病风险加剧了西班牙裔/拉丁裔成年人的大脑衰老
Ariana M Stickel1, Wassim Tarraf2, Kevin A Gonzalez3
1Department of Psychology, San Diego State University, San Diego, CA, United States.
Frontiers in aging neuroscience
|May 23, 2024
概括
高心血管疾病 (CVD) 风险和脑梗塞与西班牙裔/拉丁裔成年人的加速脑衰老有关. 这突显了心血管疾病风险因素对大脑结构和认知健康的影响.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 风险因素在西班牙裔/拉丁裔成年人中很常见,但它们对大脑结构的影响,特别是MRI心脏病发作的患病率,尚不清楚.
- 这项研究调查了心血管疾病风险因素,脑梗塞和脑结构在这个人口群体之间的关系.
研究的目的:
- 检查心血管疾病 (CVD) 风险因素和脑梗塞与西班牙裔/拉丁裔个体的大脑结构之间的关联.
- 为了确定年龄和性别是否会改变这些关联.
主要方法:
- 来自SOL-INCA-MRI研究的1886名西班牙裔/拉丁裔成年人 (50-85岁) 接受了MRI.
- 心血管疾病 (CVD) 风险使用弗雷明汉心血管风险评分评估,大约在MRI前10.5年.
- 脑结构结果包括总脑体积,灰质体积,海马体积,侧心室体积和白质超强度 (WMH) 体积.
主要成果:
- 60%的参与者具有中等或高的心血管疾病风险.
- 中等和高的心血管疾病风险与大脑总和额头灰质体积的减少以及白质超强度 (WMH) 体积的增加有关.
- 心脏病发作的存在与较低的总脑容量有关,相当于大约5年的加速脑衰老,以及较小的灰质体积.
结论:
- 在西班牙裔/拉丁裔成年人中,心血管疾病风险因素的高患病率可能导致大脑加速衰老.
- 脑梗塞与大脑体积的显著减少和加速的大脑衰老有关.
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