从零废弃物概念的加工盐中生产制药盐的再结晶方法的有效性研究
T Widjaja1, A Altway1, S Nurkhamidah1
1Chemical Engineering Department, Institut Teknologi Sepuluh Nopember, Sukolilo, Surabaya, 60111, Indonesia.
Heliyon
|May 23, 2024
概括
这项研究优化了印度尼西亚海水的制药盐生产,使用双结晶和特定化学添加剂达到99.87%的NaCl纯度. 该过程没有废物,具有可回收的副产品,但需要对原材料和技术进行重新评估,以提高市场竞争力.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
- 工业化学 工业化学 工业化学
背景情况:
- 印度尼西亚拥有丰富的海水资源,适合盐生产.
- 根据药典标准,制药盐需要高化 (NaCl) 含量和低杂质含量.
- 蒸发结晶和化学沉是提高盐质量的已知方法.
研究的目的:
- 确定从加工的原盐材料中生产制药级盐的最佳条件.
- 研究结晶时间,速度和化学添加剂 (NaOH,Na2CO3) 对盐的纯度的影响.
- 为了评估药用盐生产的单相对双结晶阶段.
主要方法:
- 盐溶于蒸水中,其中含有不同数量的NaOH和Na2CO3.
- 沉物通过过来去除.
- 过物经过103°C的蒸发结晶,单阶段或双阶段.
- 优化条件包括双结晶,20%的过量化学物质,100分钟的结晶时间和每分钟600转的速度.
主要成果:
- 在最佳条件下,制药盐含有99.87%的NaCl.
- 达到的杂质含量:Mg2+在0ppm,Ca2+在69.6ppm,SO42-在366ppm,K+在370ppm,水含量在0.166%.
- 生产过程没有产生任何废物,副产品Mg (OH) 2和CaCO3是可回收的.
结论:
- 用特定的化学添加剂和工艺参数进行双结晶是生产高纯度制药盐的有效方法.
- 开发的方法提供了一个没有废物的生产途径,具有商业价值的副产品.
- 进一步评估原材料和技术是必要的,以解决成本和市场竞争力.
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