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在MOGAD和NMOSD之间区分区域后热综合征

Ying Chen¹, Jingzi Zhangbao², Junfeng Xu¹

¹Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.

|May 23, 2024

概括

区域后综合征 (APS) 是一种罕见的表现,在髓寡细胞糖蛋白-IgG相关疾病 (MOGAD). 与神经omyelitis optica光谱障碍 (NMOSD) 相比,MOGAD患者的APS患者表现出更频繁的脑干病变和明显的恶心,吐和打模式.

科学领域:

神经免疫学神经免疫学
脱线性疾病脱线性疾病
中枢神经系统疾病中枢神经系统疾病

背景情况:

髓寡细胞糖蛋白-IgG相关疾病 (MOGAD) 和神经omyelitis optica光谱障碍 (NMOSD) 是中枢神经系统的脱髓化疾病.
这两种情况都有共同的临床特征,如视神经炎,骨髓炎和区域后风综合征 (APS).
MOGAD和NMOSD之间APS表现的差异需要进一步阐明.

研究的目的:

为了确定在MOGAD患者中APS的频率.
为了比较MOGAD和NMOSD患者中APS的特征.
为了研究两种条件的APS相关的病变和症状模式.

主要方法:

对MOG-IgG阳性APS患者 (2017-2022) 的回顾性分析.
在MOGAD和NMOSD队列之间比较APS频率,持续时间和相关病变.
在APS发作中对恶心,吐和打 (NVH) 症状的分析.

主要成果:

确定了七名MOG-IgG阳性APS患者;四人患有APS的疾病发作.
在发病时,APS发生在31/332名NMOSD患者中,在发作期间发生在47/332名患者中.
与NMOSD患者相比,APS的MOGAD患者表现出明显的NVH症状呈现,同时出现大脑干和其他脑下损伤的发病率显著更高.

结论:

区域后综合征 (APS) 是MOGAD的一个罕见但已知的表现.
在MOGAD中,APS与上和下病变的更高频率有关.
与NMOSD相比,在MOGAD中APS的独特症状模式和病变分布表明可能存在不同的表型或机制.

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