肌内或皮内mRNA-1273 SARS-CoV-2疫苗后的凝血和炎症反应:随机试验的二次分析

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Willian J van Dijk¹, Manon L M Prins², Anna H E Roukens²

¹Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Research and practice in thrombosis and haemostasis

|May 23, 2024

概括

与肌内 (IM) 接种相比,针对SARS-CoV-2的分量内皮 (ID) 接种引发了保护性抗体水平,减少了炎症. 这种ID方法可以通过尽量减少原血栓性影响来提供更安全的疫苗接种策略.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
血液学血液学血液学

背景情况:

用分量剂量的mRNA-1273 SARS-CoV-2疫苗进行皮肤内 (ID) 接种,显示抗体水平超过了对严重疾病的保护值.
与标准肌内 (IM) 疫苗接种相比,ID疫苗接种也可能与减少的前血栓效应有关.

研究的目的:

为了评估接种标准IM或分数IDmRNA-1273SARS-CoV-2疫苗后的凝血变化.
为了确定疫苗接种后炎症反应和凝血参数之间的关系.

主要方法:

一项随机对照试验比较了ID (五分之一剂量) 与IM mRNA-1273疫苗在健康成年人 (18-30岁) 的免疫性.
凝血 (血栓生成峰值高度) 和炎症 (hs-CRP) 在接种两剂疫苗之前和之后进行测量.
参与者被随机分为2:1接受ID或IM疫苗.

主要成果:

两种疫苗接种途径都暂时增加了峰值血栓生成,IM显示的增加高于ID.
与ID接种相比,肌肉内接种引发了更大的炎症反应 (hs-CRP).
内源性血栓潜在的变化与hs-CRP的变化相关.

结论:

mRNA-1273 SARS-CoV-2 疫苗接种导致与炎症相关的凝结能力暂时增加.
分剂量ID疫苗接种实现了具有较少系统性炎症的保护性抗体水平,这表明了潜在的更安全的替代方案.
ID疫苗接种可能是SARS-CoV-2疫苗的更安全的注射途径.

关键词:

2019-nCoV 疫苗的mRNA-1273是什么意思在C-反应性蛋白质中.这是一种炎症炎症炎症炎症.皮肤内注射皮肤内注射血栓形成的原因是血栓形成.接种疫苗接种疫苗

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