相关实验视频
Updated: Jun 25, 2025

07:38
Strategies for Assessing Autistic-Like Behaviors in Mice
Published on: September 20, 2024
953
自闭症谱系障碍中的雄激素水平:系统性审查和元分析
Zhao Wang1, Bohan Zhang1, Chenyu Mu1
1Department of Anatomy, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Frontiers in endocrinology
|May 23, 2024
概括
自闭症谱系障碍 (ASD) 与改变的雄激素水平有关,在患有ASD的个体中,尤其是男性中,和脱氨 (DHEA) 可能会升高. 这一元分析证实了自闭症患者群体中较高的雄激素水平.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 与荷尔蒙变化有关,特别是像丸激素和脱氨 (DHEA) 这样的雄激素.
- 考虑到性别差异,对ASD中雄激素调节的现有研究是有限的,并显示出不一致性.
- 这项研究解决了与对照人群相比,ASD患者的雄激素数据的定量总结的需要.
研究的目的:
- 量化总结血液,尿液或唾液中与对照人群相比,ASD患者的雄激素数据.
- 探索ASD人口中雄激素水平的潜在性别差异.
- 为了确定在ASD中可能发生变化的特定雄激素.
主要方法:
- 系统地搜索国际和中国数据库,查找2023年1月16日之前发表的符合条件的研究.
- 使用随机效应模型来计算总结统计数据的元分析.
- 评估出版偏差和异质性,根据年龄,性别,样本来源和测量方法进行子组分析.
主要成果:
- 分析了17项病例控制研究,涉及825名自闭症患者和669名对照患者.
- 在ASD患者中,整体雄激素水平显著更高 (SMD:0.27,P=0.01).
- 在患有ASD的个体中观察到尿液中总丸激素,尿液中脱氨 (DHEA) 和自由丸激素的升高. 在患有自闭症的男性中,DHEA的水平也升高.
结论:
- 在患有自闭症谱系障碍的人群中,雄激素水平,特别是自由,可能会升高.
- 脱氨激素 (DHEA) 的升高似乎是ASD男性的特定发现.
- 这些发现有助于理解ASD的神经内分泌方面以及潜在的基于性别的差异.
更多相关视频
相关概念视频
Autism Spectrum Disorder
83
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
83
Modeling in Therapy
70
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
70
Attention-Deficit/Hyperactivity Disorder
55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55
Social Anxiety Disorder
33
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
33
Conduct Disorder
31
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
31
Human Genetics
559
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
559

