多模式成像用于评估外周动脉疾病中的微循环:从临床实践到临床实践
Santiago Callegari1,2, Attila Feher1,3, Kim G Smolderen2,4
1Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, USA.
概括
微血管疾病 (MVD) 显著影响周围动脉疾病 (PAD) 结果,但被低估. 先进的成像技术为了解MVD提供了新的希望.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 医疗成像医学成像
背景情况:
- 周围动脉疾病 (PAD) 是一种普遍的疾病,与高死亡率和截肢风险相关.
- 微血管疾病 (MVD) 经常在PAD患者中观察到,是已知的不良结果的预测因素.
- 目前的标准实践并没有定期评估MVD,尽管它具有临床意义.
研究的目的:
- 审查当前对外周微循环解剖学和生理学的理解.
- 讨论成像在PAD中评估外周 perfusion 的作用.
- 要突出最近在PAD中MVD的分子和多模式成像方面的进展.
主要方法:
- 在PAD中对 perfusion 和分子成像进行临床前和临床研究的审查.
- 对外围微循环的成像技术进步的分析.
- 讨论多模式成像方法.
主要成果:
- 在PAD的发病和结果中,MVD起着至关重要的作用.
- 影像技术的进步可以提高对PAD病理生理学的理解.
- 改进的成像可能会导致更好的风险分层和治疗评估.
结论:
- 新的成像技术对于理解PAD中MVD至关重要.
- 多模态成像对个性化PAD管理具有前景.
- 进一步研究先进的成像技术可以改善患者的治疗结果.
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