甲基化物,但不是citalopram,降低了执行时间折扣任务的老鼠的冲动选择
Miranda F Koloski1,2,3, Alyssa Terry1, Noelle Lee1
1Mental Health, VA San Diego Medical Center, San Diego, CA, United States.
Frontiers in psychiatry
|May 23, 2024
概括
多巴胺 (甲基) 药物通过影响核来降低冲动性,而血清素 () 药物对大鼠的选择冲动性没有影响. 这突出了多巴胺.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 单胺系统药物对于冲动控制障碍是常见的.
- 氨酸和多巴胺再吸收抑制剂可能会以不同的方式影响冲动性.
- 之前的研究缺乏这些药物对冲动性的直接比较.
研究的目的:
- 直接比较多巴胺和血清激素对选择冲动性的影响.
- 调查核贝在冲动性中的作用.
- 确定多巴胺对冲动性的影响是否通过核聚合体外进行介导.
主要方法:
- 老鼠执行了一个暂时的折扣任务,在立即的小奖励或延迟的大奖励之间进行选择.
- 管理的甲基胺 (多巴胺再吸收抑制剂) 和citalopram (血清激素再吸收抑制剂).
- 损伤了核,以评估其在冲动性和药物效应中的作用.
主要成果:
- 甲基胺剂量取决于延迟奖励的偏好增加.
- 奇塔洛普拉姆对时间折扣行为没有显著影响.
- 核心 accumbens 贝损伤减少了选择冲动性,甲基酸盐在损伤后失去了它的效果.
结论:
- 状多巴胺系统通过核突的外调节选择冲动性.
- 血清激素系统可能会影响行为抑制的不同方面.
- 多巴胺在冲动性中的作用至少部分由核突介导.
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