关于恶性瘤中乳酸乳酸的综述:它在免疫治疗中的潜力
Jinhui Zha1,2, Junan Zhang3, Jingfen Lu4
1Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China.
Frontiers in immunology
|May 23, 2024
概括
乳酸,曾经是代谢的副产品,现在已知驱动瘤生长和入侵. 新的研究探讨了乳酸盐的修饰,即乳化,用于癌症免疫疗法和诊断.
科学领域:
- 生物化学 生化学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 乳酸在历史上被视为一种简单的代谢副产品.
- 新出现的证据强调了乳酸在促进瘤生长,迁移和入侵方面的关键作用.
- 乳酸的翻译后修改,称为乳酸化,在调节基因表达方面越来越被认可.
研究的目的:
- 审查乳酸和瘤免疫之间的复杂相互作用.
- 检查乳酸化在恶性瘤中的流行率和重要性.
- 探索在癌症免疫治疗中向乳酸乳酸的治疗潜力.
主要方法:
- 关于癌症中乳酸代谢的综合文献综述.
- 对研究蛋白质乳糖化在各种癌症中的研究进行分析.
- 目前和新兴的免疫治疗策略的审查,以乳化为目标.
主要成果:
- 乳酸盐积极促进瘤的进展和免疫规避.
- 基因组蛋白和非基因组蛋白的乳糖化是癌症中调节基因表达的关键机制.
- 向乳化为新型癌症免疫疗法提供了一个有希望的途径.
结论:
- 乳酸是癌症发病的一个重要驱动因素,超出了它的代谢作用.
- 蛋白质乳化是恶性瘤中至关重要的调节机制.
- 进一步研究乳酸乳化对于推进癌症诊断和治疗至关重要.
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