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自相关的ncRNAs:在消化系统新生体中的调节作用和潜在的治疗效果
Liushan Wei1, Shijie Wu1, Xiaoyong Lei1,2
1School of Pharmaceutical Science, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan421001, P.R. China.
Current medicinal chemistry
|May 23, 2024
概括
非编码RNAs (ncRNAs) 调节自,这是一个细胞过程,在癌症中具有双重作用. 了解这些ncRNA-自相互作用对于开发消化系统癌症的新治疗点至关重要.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 消化系统瘤对全球健康构成重大负担,约占癌症发病率的25%和癌症死亡率的35%.
- 早期检测和预后仍然是这些癌症的管理的主要挑战,突出需要新的治疗策略.
- 自,一个基本的细胞降解过程,在癌症的发展和进展中起着复杂而往往矛盾的作用.
研究的目的:
- 审查各种消化系统癌症中自相关的非编码RNAs (ncRNAs) 的分子机制和生物功能.
- 阐明ncRNAs在调节自的复杂作用及其对瘤发生,进展和治疗耐药性的影响.
- 探索ncRNAs作为消化系统瘤的治疗点的潜力.
主要方法:
- 文献综述侧重于自的分子机制.
- 分析与自相关的ncRNAs (miRNAs, lncRNAs, circRNAs) 的生物功能.
- 在消化系统癌症的背景下检查ncRNA介导的自调节.
主要成果:
- 自在癌症中表现出双重作用,在早期可能抑制瘤发生,同时在晚期促进瘤进展.
- 非编码RNAs (ncRNAs) 是细胞自的关键调节者,影响消化系统瘤的发病,进展,转移,复发和治疗耐药性.
- 微RNAs (miRNAs) 主要在转录后调节中起作用,而长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 则充当具有更广泛调节作用的分子海绵.
结论:
- ncRNAs和自细胞之间的复杂相互作用显著影响消化系统癌症的发展和进展.
- 准ncRNA-自途径为消化系统癌症的新型治疗干预提供了有希望的途径.
- 为了制定有效的癌症治疗策略,需要对ncRNAs在自中的多样性调节功能进行进一步的研究.
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