认知表现的集群预测了老年患者的长期认知障碍,这些老年患者有主观记忆问题和健康的对照
Adolfo Jiménez-Huete1, Rafael Villino-Rodríguez1, Mirla M Ríos-Rivera1
1Department of Neurology, Clínica Universidad de Navarra, Madrid, Spain.
概括
主观记忆投诉 (SMC) 显示出不同的认知集群. 较低的认知表现集群预测认知衰退,并显示早期阿尔茨海默病的生物标志物,即使在健康个体.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 老年学是一门学科.
背景情况:
- 主观记忆问题 (SMC) 可能代表不同的患者子组,具有不同的认知障碍风险.
- 在SMC中识别不同的认知概况对于理解认知衰退轨迹至关重要.
研究的目的:
- 在SMC和健康对照 (HC) 个体中识别和描述认知集群.
- 评估这些集群对认知障碍的预测价值及其与生物标记物的关联.
主要方法:
- 集群分析应用于来自两个独立的SMC和HC队列的人口统计和神经心理数据.
- 使用生存分析和贝叶斯模型平均值来评估基于集群的风险预测和生物标志物协会.
主要成果:
- 在SMC和HC组中发现了两个不同的认知集群 (高和低平均表现).
- 被分配到较低表现的集群显著增加了认知障碍的风险 (HRs: 1.78,2.96).
- 较低的性能集群与海马体积的减少和脑脊液/粉样β 42比率的升高有关,这表明阿尔茨海默病的病理学已经开始.
结论:
- 在SMC和HC种群中存在具有生物学意义和认知衰退预测价值的认知集群.
- 鉴定出较低表现的集群代表了一个具有生物学意义的子组,具有较高的认知障碍风险.
- SMC对认知能力下降风险的影响很小,并受到情绪等混因素的影响.
关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.贝叶斯模型的平均值是贝叶斯的模型.生物标志物 生物标志物集群分析集群分析集群分析认知障碍是一种认知障碍.神经心理学概况 神经心理学概况主观记忆抱怨的主观记忆抱怨更多相关视频
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