在百万退伍军人计划中,色剂暴露和前列腺癌风险
Meghana S Pagadala1, Asona J Lui2, Allison Y Zhong2
1Research Service, VA San Diego Healthcare System, San Diego, CA, USA; Medical Scientist Training Program, University of California San Diego, La Jolla, CA, USA; Biomedical Science Program, University of California San Diego, La Jolla, CA, USA.
Acta oncologica (Stockholm, Sweden)
|May 23, 2024
概括
在越南退伍军人中,假定的色剂暴露与现代队列中致命或转移性前列腺癌 (PCa) 的更高风险没有显著联系. 进一步的分析表明,它可能不是当前PCa风险分层的关键因素.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 退伍军人健康 退伍军人的健康
背景情况:
- 在色剂时代在越南服役的退伍军人被认为暴露于前列腺癌 (PCa) 的高风险.
- 这项研究调查了假设的色剂暴露是否是当代退伍军人中晚期或致命的PCa的独立风险因素.
研究的目的:
- 确定假设的色剂暴露与任何PCa,转移性PCa或PCa特异性死亡率的风险之间的独立关联.
- 在考虑种族/种族,家族病史和遗传倾向时,评估色剂暴露对PCa风险的影响.
主要方法:
- 利用了301,470名在越南战争时期活跃的百万退伍军人计划 (MVP) 的参与者的数据.
- 根据美国政府的定义评估色剂的暴露,并使用多基因危险评分量化基因风险.
- 采用Cox的比例危险模型来分析PCa诊断,转移和死亡率的关联.
主要成果:
- 无变量分析显示,剂暴露与PCa,转移PCa或PCa死亡风险增加之间没有显著的关联.
- 在调整了种族/种族和家族史后,色剂暴露与PCa风险增加有轻微的独立关联,但没有转移PCa或PCa死亡.
- 考虑到遗传风险,也得出了类似的结果,这表明先前接触过色剂可能不会提高目前的PCa风险分层.
结论:
- 据推测,单独暴露于色剂似乎并不是当代退伍军人队伍中晚期或致命的前列腺癌的重要独立预测因素.
- 种族/种族,家族史和遗传风险等因素在现代PCa风险评估中似乎比色剂暴露更有影响.
- 在今天的退伍军人中,色剂暴露史可能不是提高前列腺癌风险分层的准确性至关重要的组成部分.
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