用于急性呼吸道感染的早期治疗的NSAID
Matteo Bassetti1,2, Massimo Andreoni3,4, Pierachille Santus5,6
1Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova.
Current opinion in infectious diseases
|May 23, 2024
概括
早期使用非类固醇抗炎药物 (NSAIDs) 可以通过减少炎症来帮助管理病毒急性呼吸道感染 (ARIs) 的症状. 有证据表明,NSAIDs在像COVID-19这样的疾病中对症状控制是安全和有效的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 病毒性急性呼吸道感染 (ARTIs) 涉及一种炎症级联.
- 促炎性细胞因子在COVID-19等感染中驱动呼吸系统和全身症状.
- 关于在SARS-CoV-2中使用NSAID存在担忧,但现在有证据支持它们的安全性.
研究的目的:
- 审查NSAID早期干预病毒性ARTIs的理由.
- 探索NSAIDs在缓解炎症并发症方面的潜在临床益处.
- 评估NSAIDs在症状管理和预防不适当使用抗生素中的作用.
主要方法:
- 实验研究的审查.
- 观察性临床研究的分析.
- 随机临床试验和元分析的综合.
主要成果:
- 无抗炎药有效控制病毒性呼吸道感染的症状,包括COVID-19.
- 没有证据支持限制NSAID使用,因为增加了易感性或疾病恶化.
- 无抗炎药物代表了一种可行的自我护理选择,用于症状管理.
结论:
- 炎症反应是早期ARTIs的关键.
- 及时的NSAID治疗可以控制病理机制并减少患者的症状.
- 及时使用NSAID可以防止不必要的抗生素处方,打击耐药性.
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