通过血小板介导的循环瘤细胞从通过免疫检查点CD155-TIGITIT杀死自然杀手细胞逃离
Yunfan Sun1, Tong Li2, Lin Ding2
1Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China.
Hepatology (Baltimore, Md.)
|May 23, 2024
概括
循环瘤细胞 (CTC) 使用血小板粘附来逃避自然杀手 (NK) 细胞的杀死,通过调节CD155. 阻止CD155-TIGIT相互作用可以恢复NK细胞对转移的免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 细胞和分子医学 细胞和分子医学
背景情况:
- 循环瘤细胞 (CTCs) 驱动癌症转移,但它们逃避免疫监测的理解不充分.
- 了解CTC如何避免免疫检测对于开发有效的癌症疗法至关重要.
研究的目的:
- 研究CTC在血液传播过程中逃避自然杀手 (NK) 细胞介导免疫监测的机制.
- 确定阻止CTC免疫逃避和预防转移的潜在治疗点.
主要方法:
- 单细胞RNA测序和多重免疫光在各种癌症类型的血液样本上.
- 在体外,体外和体内测试以研究CTC-血小板相互作用和NK细胞细胞毒性.
- 涉及FAK/JNK/c-Jun级联和竞争试验的机制研究,以分析免疫检查点的参与.
主要成果:
- 确定了CTC-血小板粘附,并且与肝细胞癌 (HCC) 患者的生存率降低有关.
- 与血小板结合的CTC上调了CD155,抑制了NK细胞的杀死并促进了转移.
- CD155-TIGIT相互作用被确定为NK细胞逃避的主要机制,与CD96和DNAM1.1不同.
- 阻止CD155-TIGIT与抗体的相互作用恢复了NK细胞的活性,并减少了转移.
结论:
- 通过CD155-TIGIT免疫检查点,CTCs通过血小板粘附来促进NK细胞免疫监测.
- 向CD155-TIGIT通路是一个有前途的免疫治疗策略,可以消除CTC并防止癌症扩散.
更多相关视频
相关概念视频
Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Cytotoxic T Cells-mediated Immune Response
892
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
892
Cells of the Innate Immune Response
1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K


