肥胖中的左心室缩功能障碍:跟踪斑点的元分析心声回声学研究
Elisa Gherbesi1, Andrea Faggiano1,2, Carla Sala1,2
1Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico.
Journal of hypertension
|May 23, 2024
概括
肥胖会损害心脏功能,全身纵向应变 (GLS) 揭示了排气失调缺失的排气分数 (LVEF). 在肥胖个体中,GLS对于检测早期心脏损伤至关重要.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心血管研究研究心血管研究
背景情况:
- 肥胖是左心室缩 (LVH) 和腹功能障碍的重要危险因素.
- 有证据表明,在肥胖个体中心肌变形受损,即使没有明显的缩功能障碍.
- 之前的发现是基于单个研究,需要进行全面的分析.
研究的目的:
- 在肥胖患者中对心肌变形受损进行元分析.
- 提供关于肥胖心脏机制的全面和最新信息.
- 调查全球纵向应变 (GLS) 在检测亚临床心脏损伤方面的有用性.
主要方法:
- 在PubMed,OVID-MEDLINE和Cochrane数据库中搜索到2023年12月31日.
- 包括英语文章,使用关键词与心肌应变,心脏力学和肥胖有关.
- 分析了24项涉及5792名肥胖者和5518名非肥胖者的研究.
主要成果:
- 在肥胖个体中,全球纵向菌株 (GLS) 显著受损 (SMD -0.86).
- 左心室喷射分数 (LVEF) 也显示出显著的差异,但不那么敏感.
- 在晚期肥胖症 (BMI > 35 kg/m2) 中,GLS比LVEF更有效地检测到心功能障碍.
结论:
- 全球纵向菌株 (GLS) 可以识别肥胖患者的亚临床缩功能障碍,常常被LVEF遗漏.
- 应该将GLS纳入对肥胖个体的常规评估中.
- 这种方法有助于识别肥胖引起的亚临床心脏损伤.
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