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Updated: Jun 25, 2025

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乙醇通过改变以Rab5为中心的LD溶酶体贩运来破坏肝细胞脂质

Micah B Schott1, Cody N Rozeveld1, Saumya Bhatt1

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Hepatology communications
|May 23, 2024
PubMed
概括

小型GTPase Rab5对于肝细胞中的脂滴 (LD) 分解至关重要,因为它促进了溶酶体的接近. 长期暴露于酒精会损害Rab5的功能,导致脂肪积累 (肝硬化症).

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