局部使用的5-fluorouracil 0.5%作为眼睛表面状新生病的初级治疗方法
Gabriela Carneiro Teixeira1, Mateus Inacio Lemes de Resende1, Melina Correia Morales1
1Department of Visual Sciences and Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
European journal of ophthalmology
|May 23, 2024
概括
局部使用的5-Fluorouracil (5-FU) 0.5%有效治疗眼表面状新生病 (OSSN),成功率为80%. 这种治疗选择耐受性很好,尽管较大的病变大小可能会降低成功的机会.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
背景情况:
- 眼表面状新生病 (OSSN) 是结膜的前恶性病变.
- 目前OSSN的治疗选择包括手术切除和局部化疗.
研究的目的:
- 为了评估局部5-Fluorouracil (5-FU) 0.5%治疗OSSN的疗效和耐受性.
主要方法:
- 一项前性研究,涉及30名临床诊断为OSSN的患者.
- 患者接受了局部5-FU0.5%每天四次,持续10天,然后是3周的药物假期,长达3个周期.
- 监测了治疗的坚持和不良事件.
主要成果:
- 80%的患者 (共30人中24人) 在局部5-FU0.5%的治疗中取得了治疗成功.
- 平均治疗持续时间为21.71天.
- 病变区域增加1mm2时,治疗成功率降低了6% (p=0.033).
- 在8名患者中报告了眼部不适等轻度不良事件.
结论:
- 局部5-FU0.5%显示显著的疗效和良好的耐受性OSSN治疗.
- 损伤大小是影响治疗结果的关键因素,应指导治疗决策.
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