接受过透析的已故捐献者的移植结果
Yumeng Wen1, Sherry G Mansour2, Nityasree Srialluri1
1Division of Nephrology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
JAMA
|May 23, 2024
概括
在捐献前接受透析的已故捐献者的移植患者有较高的延迟移植功能风险. 然而,与未接受透析的捐赠者的脏相比,长期移植失败和死亡率相似.
科学领域:
- 肝脏病学
- 移植免疫学
- 器官捐赠
背景情况:
- 在捐献之前接受过透析的已故捐献者的器官接受移植的患者的结果尚未确定.
- 了解这些结果对于优化器官利用和接受者护理至关重要.
研究的目的:
- 将接受过透析的已故捐赠者的脏接受者与在捐献前没有透析的接受者的结果进行比较.
主要方法:
- 一项回顾性队列研究分析了58个美国器官采购组织 (2010-2018) 的数据.
- 接受过透析的已故脏捐赠者 (n=805) 与没有接受透析的脏捐赠者进行了1:1匹配.
- 对接受移植的人 (n=1944) 进行了延迟移植功能,移植失败和死亡的评估.
主要成果:
- 接受透析的捐赠者的移植与延迟移植功能 (59. 2% vs 24. 6%) 的风险显著增加.
- 在34. 1个月的中位随访期内,没有观察到任何原因的移植失败,死亡审查的移植失败或死亡率的显著差异.
结论:
- 在捐赠之前接受过透析的已故捐赠者的脏增加了移植功能延迟的风险.
- 这两组捐赠者的衰竭和死亡率相似, 表明这些可以安全地移植.
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