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骨细胞的解剖学参数及其与解剖学,遗传学或综合征性形的关联:一个回顾性研究
Gallien Parata1, Yvan Vial2, Marie-Claude Addor3
1Service médico-chirurgical de pédiatrie, Hôpital du Valais, Sion, Switzerland.
Pediatric surgery international
|May 23, 2024
概括
腹的大小和肝脏参与并不能预测活产生的相关形或遗传异常. 然而,胎儿形和重大形,遗传问题或综合征的胎儿更有可能因为胎儿异常而进行妊娠终止.
科学领域:
- 医学遗传学 医学遗传学
- 胎儿医学 胎儿医学
- 儿科手术 儿科手术
背景情况:
- 腹腔是一种先天性腹壁缺陷,结果各不相同.
- 相关异常,包括遗传和综合征状况,显著影响预后.
- 了解解剖学参数对于预测结果和指导管理至关重要.
研究的目的:
- 描述腹细胞的解剖学参数.
- 分析囊特征与解剖学,遗传学或综合征性形之间的关联.
- 调查怀孕结果的预测因素,包括活产,因为胎儿异常而终止怀孕和胎儿死亡.
主要方法:
- 从1998年到2018年,对162个腹病例进行了回顾性分析.
- 包括活产 (LB),由于胎儿异常导致的妊娠终止 (TOPFA) 和胎儿死亡 (FD) 的病例.
- 排除了来自西瑞士以外的病例和那些有上部或下部胆固醇体的病例.
主要成果:
- 由于胎儿异常 (TOPFA) 导致的妊娠终止在非隔离的乳头病例中明显更为常见,特别是那些心血管和生殖尿道形,遗传/染色体异常或综合征的病例.
- 在活产儿 (LB) 中,腹细胞大小和肝脏参与与相关解剖形,遗传或染色体异常的存在或数量无关.
- 该队列包括57例活产 (35%),91例TOPFA (56%) 和14例胎儿死亡 (9%).
结论:
- 由于胎儿异常 (TOPFA) 的妊娠终止率在出现重大发育不全或遗传/染色体异常的胎儿中较高.
- 与之前的一些研究相反,囊大小和肝脏参与并不是可靠的指标来预测相关的形或遗传异常.
- 这些发现凸显了在尾病例中进行全面的遗传和解剖评估的重要性,无论缺陷的大小如何.
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