以免疫疗法治疗的高级非小细胞肺癌的身体组成
Tafadzwa L Chaunzwa1,2, Jack M Qian2, Qin Li3
1Artificial Intelligence in Medicine Program, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.
JAMA oncology
|May 23, 2024
概括
癌症治疗期间的骨肌肉质量的损失与非小细胞肺癌 (NSCLC) 患者,特别是男性患者的结果更差有关. 皮下脂肪组织密度的变化也会影响预后,特别是在女性身上.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 身体组成分析 身体成分分析
背景情况:
- 在非小细胞肺癌 (NSCLC) 中,身体成分 (BC) 和癌症结局之间的关系是复杂的,并未完全理解.
- 在NSCLC中对BC的先前研究仅限于小规模研究,结果各不相同.
研究的目的:
- 调查接受免疫治疗的晚期或转移性NSCLC患者的身体组成和瘤结果之间的关联.
- 评估系统治疗期间骨肌肉和脂肪组织变化的预后意义.
主要方法:
- 对1791名接受免疫疗法,化疗免疫疗法或化疗治疗的NSCLC患者进行了多队列分析.
- 基线和后续CT扫描使用深度神经网络分析骨肌肉 (SM) 和皮下脂肪组织 (SAT) 分段.
- 基于基线BC测量结果和第一次随访时的变化结果的比较.
主要成果:
- 骨肌肉质量的损失与患者群体的整体存活率 (OS) 和无进展存活率 (PFS) 更差,特别是在男性中.
- 皮下脂肪组织密度增加与三个队列中较差的OS相关,主要在女性患者中观察到.
- 危险比率表明BC变化与生存结果之间存在显著的关联.
结论:
- 系统治疗期间的骨肌肉质量损失是NSCLC预后不佳的标志物,特别是在男性患者中.
- 皮下脂肪组织密度的变化也具有预后性,女性患者有显著的关联.
- 自动CT衍生体质测量对于NSCLC预后评估非常有价值.
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