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较大的冷漠与选择性色素再吸收抑制剂在帕金森病中的使用有关
Rachel N Schade1, Connor B Etheridge1, Lauren E Kenney1
1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Journal of geriatric psychiatry and neurology
|May 23, 2024
概括
选择性血清素再吸收抑制剂 (SSRI) 与帕金森病 (PD) 患者的冷漠性增加有关. 这表明,仔细选择抗抑郁药对于管理PD中的冷漠至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 运动障碍 运动障碍
背景情况:
- 漠不关心是帕金森病 (PD) 的常见动机缺陷,经常被误诊为抑郁症.
- 选择性血清素再吸收抑制剂 (SSRI) 与其他人群的冷漠性增加有关.
- 血清激素在PD中降低多巴胺基系统的潜力,需要对SSRI使用和无动于衷进行调查.
研究的目的:
- 调查选择性血清素再吸收抑制剂 (SSRI) 使用与帕金森病 (PD) 患者的冷漠之间的关系.
- 为了确定SSRI是否与PD患者的其他抗抑郁药类相比与冷漠有独特的关联.
主要方法:
- 评估了400名患有PD的个人的方便样本.
- 收集的数据包括药物使用,情绪/动机量表 (贝克抑郁量表-II,冷漠度表) 和临床信息.
- 抗抑郁药物按作用机制进行分类进行分析.
主要成果:
- 在帕金森病 (PD) 样本中的26%被处方为SSRI.
- 层次回归分析表明,SSRI与较高的冷漠度得分有显著的关联 (β = .1,P = .02).
- 教育水平较低,认知能力较差,抑郁症得分较高也预测了冷漠度的增加.
结论:
- 与其他抗抑郁药不同的是,SSRI使用与帕金森病 (PD) 患者的冷漠感显著相关.
- 调查结果强调,在给PD患者开抗抑郁药时,要考虑无动于衷,这是由于血清素-多巴胺相互作用导致的.
- 从SSRI转换为替代抗抑郁药可能是PD无动于衷的潜在治疗策略,需要进一步研究.
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