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Updated: Jun 25, 2025

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
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An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

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关于建立基于血清酶整合酶的平台的议定书,用于对真核细胞中遗传切换控制器的功能验证

Marco A de Oliveira1,2, Lilian H Florentino1,2,3, Thais T Sales1,2,3

  • 1Department of Cell Biology, Institute of Biological Science, University of Brasília, Brasília, Distrito Federal, Brazil.

PloS one
|May 23, 2024
PubMed
概括

这项研究引入了一个新的平台,用于工程氨酸整合酶 (Int) 基因开关,用于控制真核生物中的基因表达. 该系统能够发现和验证用于医药和农业应用的新药.

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相关概念视频

Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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