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Updated: May 10, 2026

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
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Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites

Published on: March 16, 2018

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在莱什马尼亚感染的人类巨细胞中含有阿尔戈诺特蛋白质复合物的表征

Atieh Moradimotlagh1, Harsimran Kaur Brar1, Stella Chen1

  • 1Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, B.C, Canada.

PloS one
|May 23, 2024
PubMed
概括

莱什马尼亚寄生虫为了生存而操纵宿主巨细胞RNA干扰 (RNAi) 复合体,包括阿尔戈诺特 (Ago) 蛋白质. 这项研究揭示了宿主RNA诱导沉默复合体 (RISC) 中的Leishmania蛋白,这表明了新的治疗点.

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相关概念视频

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...