脆弱性和系统性动脉样硬化风险:双向的门德尔随机化研究
Liugang Xu1, Yajun Wang1, Hongyun Ji1
1Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, People's Republic of China.
PloS one
|May 23, 2024
概括
虚弱指数 (FI) 基因预测冠状动脉和脑动脉样硬化风险增加. 这项研究证实了虚弱性和动脉样硬化之间的双向因果关系,影响三糖和LDL-C水平.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 观察性研究表明,虚弱和动脉样硬化之间存在联系.
- 在各种解剖学部位的脆弱性和动脉样硬化之间的因果关系需要澄清.
研究的目的:
- 调查脆弱指数 (FI) 和系统性动脉样硬化之间的因果关系.
- 评估FI与冠状动脉,大脑和外周动脉动脉硬化之间的双向因果关系.
- 评估FI与脂质样本 (LDL-C,HDL-C,甘油三) 之间的关联.
主要方法:
- 双向门德尔随机化 (MR) 研究设计.
- 利用大规模的全基因组关联研究 (GWAS) 对脆弱性,各种动脉样硬化表型和脂质水平的总结统计数据.
- 采用逆方差加权 (IVW),逆MR和多变量MR分析来评估因果关系和逆因果关系.
主要成果:
- 基因预测FI与冠状动脉 (OR=1.47) 和脑动脉样硬化 (OR=1.99) 的风险增加有关.
- 基因预测FI显示与甘油三酸 (OR=1.31) 有正相关性,与LDL-C (OR=0.87) 有负相关性.
- 反向和多变量MR分析证实了系统性动脉样硬化,脂质和FI增加之间的双向因果关系.
结论:
- 基因预测的脆弱指数与冠状动脉和脑动脉样硬化有因果关系.
- 在脆弱性和动脉样硬化之间存在双向因果关系.
- 虚弱与改变的甘油三和LDL-C水平有因果关系,需要为脆弱人群提供量身定制的护理.
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