开发具有pH反应的Eudragit S100功能化的丝纤维蛋白纳米颗粒,作为潜在的药物输送系统
Duy Toan Pham1, Doan Xuan Tien Nguyen1, Ngoc Yen Nguyen1
1Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.
PloS one
|May 23, 2024
概括
这项研究开发了Eudragit S100功能化丝纤维蛋白纳米颗粒 (ES100-FNP) 用于pH响应药物输送. 在模拟的肠道条件下,ES100-FNP系统证明了罗西米德的受控释放,显示出生物医学应用的高度多功能性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 丝纤维素纳米粒子 (FNP) 为生物医学用途提供生物相容性和生物降解性.
- 从FNP中控制药物释放对于增强其治疗多功能性至关重要.
- 欧德拉吉特S100的功能化创造了pH响应药物递送能力.
研究的目的:
- 开发Eudragit S100功能化的FNP (ES100-FNP) 作为一个pH响应的药物递送系统.
- 研究两种方法 (共凝和吸附) 来产生ES100-FNP.
- 评估开发的ES100-FNP. 的罗塞米德捕获和释放特征.
主要方法:
- 使用动态光散射 (DLS),电子显微镜和UV-Vis光谱学进行粒子表征.
- 在各种pH条件下评估药物捕获效率和释放概况.
- 使用FT-IR,XRD和DSC分析化学结构和热稳定性.
主要成果:
- ES100-FNP表现出纳米尺寸 (200-350 nm) 和负泽塔电位 (-20 mV).
- 同冷凝产生球形颗粒,吸附产生榴莲形颗粒.
- 在模拟的胃条件下ES100-FNP保护了furosemide,并在模拟的肠条件下释放它,释放速度取决于配方方法和pH值.
结论:
- ES100-FNP是一款灵活的响应pH的药物输送系统.
- 配方方法显著影响粒子形态和药物释放动力学.
- 开发的ES100-FNP对先进的生物医学药物输送应用具有前景.
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