运动可以预防艾滋病毒感染者血管加速衰老
Raymond Jones1, Austin T Robinson2, Lauren B Beach3,4
1Heersink School of Medicine, University of Alabama at Birmingham, AL (R.J.).
Circulation research
|May 23, 2024
概括
艾滋病毒感染者 (PLWH) 面临心血管疾病 (CVD) 风险增加,原因是持续的炎症和ART毒性. 运动可以减轻加快的血管衰老,并降低心血管疾病的风险在这个人群中.
科学领域:
- 心血管健康 心血管健康
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 抗逆转录病毒疗法 (ART) 改善了艾滋病毒存活率,但感染艾滋病毒的人 (PLWH) 患有更高的心血管疾病 (CVD) 风险.
- 这种增加的风险与持续的免疫激活,ART毒性和加速的血管衰老有关.
- 心血管疾病是PLWH的主要死亡原因,差异受社会决定因素和心理社会压力的影响.
研究的目的:
- 审查PLWH中心血管疾病的流行病学和病理生理学.
- 探索加速血管衰老的机制,包括免疫激活,炎症,氧化应激,肠道微生物组变化和心理社会压力.
- 检查运动在缓解心血管疾病风险和血管衰老中的作用.
主要方法:
- 在PLWH中对心血管疾病流行病学和病理生理学的文献综述.
- 关于加快血管衰老机制的当前研究的综合.
- 分析运动方式及其对血管健康的影响.
主要成果:
- 与一般人群相比,PLWH患心血管疾病的风险是2倍以上.
- 过早的血管功能障碍是PLWH中心血管疾病风险的早期决定因素.
- 免疫激活,慢性炎症,氧化压力,肠道微生物组变化和心理社会压力都导致血管衰老加速.
结论:
- 加快的血管衰老是PLWH中心血管疾病风险的一个关键因素.
- 运动干预措施在改善血管健康和潜在地废除血管衰老方面表现有前途.
- 需要进一步的包容性研究,以了解和管理CVD风险在多样化的PLWH群体整体.
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