与艾滋病毒感染者生活的老年人心脏和脏并发症
Keir McCutcheon1, Unati Nqebelele2,3, Lyle Murray4
1Lady Pohamba Private Hospital, Windhoek, Namibia (K.M.).
Circulation research
|May 23, 2024
概括
患有人类免疫缺陷病毒 (HIV) 的老年人面临心脏和脏疾病的风险增加,原因是慢性炎症,由抗逆转录病毒联合治疗加剧. 本综述探讨了老龄化艾滋病毒人口中这些复杂的相互作用.
科学领域:
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 人类免疫缺陷病毒 (HIV) 疫情已经转向人口老龄化,全球约有3900万艾滋病毒感染者.
- 联合抗逆转录病毒疗法 (cART) 将艾滋病毒转化为慢性疾病,改善了预期寿命,但引入了新的挑战.
- 衰老本身会加剧氧化应激和全身炎症,这些影响在艾滋病毒感染者中可能会被放大.
研究的目的:
- 审查与艾滋病毒相关的慢性炎症,cART和与艾滋病毒 (PLWH) 携带的老年人心脏和脏并发症的发展之间的相互作用.
- 检查PLWH队列中人口向老年人口的变化.
- 阐明导致老龄化PLWH对心脏和脏疾病的敏感性增加的病理生理机制.
主要方法:
- 这是一个叙事综述,综合了当前的文献.
- 该综述侧重于与艾滋病毒,cART,衰老,炎症和并发症有关的病理生理机制.
- 检查了当代世界卫生组织报告和科学文献的数据.
主要成果:
- 老龄化PLWH表现出对心脏和脏并发症的增强敏感性.
- 慢性炎症,由艾滋病毒驱动,并可能由cART调节,是关键因素.
- 与衰老相关的氧化应激在PLWH中被放大,导致疾病的发展.
结论:
- 老龄化的PLWH患心脏和脏并发症的风险明显更高.
- 了解PLWH加速衰老和炎症的机制对于管理长期健康至关重要.
- 需要进一步的研究来开发有针对性的干预措施,以减轻日益老龄化的艾滋病毒人口中的这些风险.
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