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Updated: Jun 25, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication

Published on: August 23, 2024

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由于CBX3的CK2-依赖性降解,导致复制分叉停滞和PARP抑制剂敏感性

Jian Ma1, Dianyun Ren2, Zixi Wang1

  • 1Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Science advances
|May 23, 2024
PubMed
概括

染色体蛋白同源3 (CBX3) 结合RPA2,控制DNA复制叉的稳定性. 抑制或降解CBX3促进复制重启,在癌症治疗中具有潜力.

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